ABSTRACT
BACKGROUND AND OBJECTIVES: Nonsteroidal anti-inflammatory durgs (NSAIDs) are now widely accepted analgesics for posttonsillectomy patients, but their ability to inhibit platelet cyclooxygenase (COX) may be associated with a risk of increased bleeding after tonsillectomy. Rofecoxib, the recently introduced selective COX-2 inhibitor, may have advantages for analgesics in tonsillectomy in that they produce minimal effects on platelet aggregation. But the analgesic efficacy of rofecoxib in tonsillectomy has not been made known yet. The aim of our randomized prospective study was to compare the analgesic efficacy of rofecoxib, the selective COX-2 inhibitor, and ibuprofen, the classic NSAID, for the posttonsillectomy pain management. We also evaluated the influence of both drugs on the posttonsillectomy bleeding. SUBJECTS AND METHOD: Thirty-eight adult patients undergoing tonsillectomy were randomly divided into either ibuprofen or rofecoxib group. Patients received either oral ibuprofen (600 mg, three times a day) or oral rofecoxib (25 mg, twice a day). Patients recorded pain levels twice daily for 7 days using a visual analogue scale. Posttonsillectomy hemorrhage was recorded in each groups. RESULTS: Pain scores for the 7 days were not significantly different between two groups, but the rofecoxib group reported less pain. Rofecoxib group felt more satisfactorily about early control of postoperative pain. There was no significant difference in the incidence of postoperative hemorrhage between two groups. CONCLUSION: Rofecoxib is as effective as ibuprofen for postoperative pain control in adult tonsillectomy, which might be beneficial for avoiding the adverse effects of NSAIDs.
Subject(s)
Adult , Humans , Analgesics , Anti-Inflammatory Agents, Non-Steroidal , Blood Platelets , Hemorrhage , Ibuprofen , Incidence , Pain Management , Pain, Postoperative , Platelet Aggregation , Postoperative Hemorrhage , Prospective Studies , Prostaglandin-Endoperoxide Synthases , TonsillectomyABSTRACT
The parotid gland is the most commonly infected salivary gland. Parotid abscess occurs mostly in elderly persons who are debilitated by systemic illness. Staphylococcus aureus and anaerobic bacteria are mostly cultured in aspirates of pus from parotid abscess. We report a case of a parotid abscess that grew Candida glabrata on culture after fine-needle aspiration biopsy. This organism has not been previously associated with this condition.
Subject(s)
Aged , Humans , Abscess , Bacteria, Anaerobic , Biopsy, Fine-Needle , Candida glabrata , Candida , Parotid Gland , Salivary Glands , Staphylococcus aureus , SuppurationABSTRACT
BACKGROUND AND OBJECTIVES: Intratympanic injection is used for treatment of various inner ear diseases. We studied the effect of intratympanic steroid injection for sudden sensorineural hearing loss (SSNHL). MATERIALS AND METHOD: We carried out a retrospective review of 40 patients with SSNHL with oral steroid therapy and 32 patients with SSNHL with intratympanic steroid injection. Intratympanic steroid injection was performed with tuberculin syringe with a 25-gauge spinal needle under local anesthesia. Hearing was assessed immediately before therapy and at 3 weeks after therapy. RESULTS: Hearing improvement was documented in 25 of 40 patients (62.5%) in the oral steroid therapy group and 21 of 32 patients (65.6%) in the intratympanic steroid therapy group. CONCLUSION: Intratympanic steroid injection was a safe and effective treatment method for SSNHL. This method may be another treatment modality for patients with SSNHL ; moreover, it is a prior treatment method for patients with systemic disease such as diabetes mellitus or hypertension.